Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

Michael V. Berridge; Renata Zobalova; Stepana Boukalova; Andrés Caicedo; Stuart A. Rushworth; Jiri Neuzil

doi:10.1016/j.ccell.2025.03.002

Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

Michael V. Berridge^*
, Renata Zobalova
, Stepana Boukalova
, Andrés Caicedo
, Stuart A. Rushworth
, Jiri Neuzil^*

^*Autor correspondiente de este trabajo

Malaghan Institute of Medical Research
Institute of Biotechnology of the Academy of Sciences of the Czech Republic
Mito-Act Research Consortium
University of East Anglia
Griffith University
Charles University

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19 Citas (Scopus)

Resumen

Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.

Idioma original	Inglés
Páginas (desde-hasta)	803-807
Número de páginas	5
Publicación	Cancer Cell
Volumen	43
N.º	5
DOI	https://doi.org/10.1016/j.ccell.2025.03.002
Estado	Publicada - 12 may. 2025

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title = "Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance",

abstract = "Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.",

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T2 - Potential clinical relevance

AU - Berridge, Michael V.

AU - Zobalova, Renata

AU - Boukalova, Stepana

AU - Caicedo, Andrés

AU - Rushworth, Stuart A.

AU - Neuzil, Jiri

PY - 2025/5/12

Y1 - 2025/5/12

N2 - Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.

AB - Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.

UR - https://www.scopus.com/pages/publications/105000676829

U2 - 10.1016/j.ccell.2025.03.002

DO - 10.1016/j.ccell.2025.03.002

M3 - Comentario/Debate

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VL - 43

SP - 803

EP - 807

JO - Cancer Cell

JF - Cancer Cell

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Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

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