The restrictions triggered by the COVID-19 pandemic, especially during the first weeks of confinement in 2020, entailed marked changes concerning urban socio-spatial relations. This article analyzes perceptions of the importance of public space, neighbors' support, neighborhood safety, and home safety before and during the initial months of the COVID-19 lockdown. We conducted an online survey between March and April 2020 in Quito, Ecuador, and applied quantitative and spatial methods to analyze the perceptions. The results show statistically significant differences in neighbors’ support, home safety, and neighborhood safety between normal days and lockdown days. The perceptions of the public space as non-important before the lockdown and the perceptions of not being safe at home or in the neighborhood are spatially random, not concentrated in a specific area of the city. Our findings also show that gender, the importance of public space during normal days, and the willingness of neighbors to support each other on lockdown days could explain the perception of the importance of public space on lockdown days. This research provides unique information to contribute with perspectives and discussions of public space and social dynamics in pandemic and post pandemic times.