Improving methods for epidemiological control of canine visceral leishmaniasis based on a mathematical model. Impact on the incidence of the canine and human disease

Clarisa B. Palatnik-De-Sousa, Leopoldina M. Batista-De-Melo, Gulnara P. Borja-Cabrera, Marcos Palatnik, Carlile C. Lavor

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

33 Citas (Scopus)

Resumen

The mathematical model described by Dye (1996) condemned the epidemiological canine visceral leishmaniasis control campaign, considering it non-efficient. Using this model, we mathematically demonstrate that the control is not efficient, only at low κ values (rate at which latent and infectious dogs are lost by the destruction program) which match the canine seropositivity observed in the field by the immunofluorescency (IF) blood eluates analysis. With higher k values, corresponding to IF (κ = 0.07) or ELISA (κ = 0.25) results in sera samples, the number of infectious dogs declines to a R0 = 1 or R0 = 0, respectively, interrupting the transmission and the advancement of epidemics. We also experimentally demonstrate that the dog removal, following the results of IF of sera, instead of eluates lead to a 57% (p < 0.005) decrease in canine cases and 87.5% (p < 0.005) in human cases. Our mathematical and experimental results indicate that the control campaign become more efficient by enhancing the sensitivity of the diagnostic assay.

Idioma originalInglés
Páginas (desde-hasta)583-593
Número de páginas11
PublicaciónAnais da Academia Brasileira de Ciencias
Volumen76
N.º3
DOI
EstadoPublicada - sep. 2004
Publicado de forma externa

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