In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis)

Leonel E. Rojo, David Ribnicky, Sithes Logendra, Alex Poulev, Patricio Rojas-Silva, Peter Kuhn, Ruth Dorn, Mary H. Grace, Mary Ann Lila, Ilya Raskin

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

181 Citas (Scopus)


We used a murine model of type II diabetes, which reproduces the major features of the human disease, and a number of cellular models to study the antidiabetic effect of ANC, a standardised anthocyanin-rich formulation from Maqui Berry (Aristotelia chilensis). We also isolated delphinidin 3-sambubioside-5-glucoside (D3S5G), a characteristic anthocyanin from Maqui Berry, and studied its antidiabetic properties. We observed that oral administration of ANC improved fasting blood glucose levels and glucose tolerance in hyperglycaemic obese C57BL/6J mice fed a high fat diet. In H4IIE rat liver cells, ANC decreased glucose production and enhanced the insulin-stimulated down regulation of the gluconeogenic enzyme, glucose-6-phosphatase. In L6 myotubes ANC treatment increased both insulin and non-insulin mediated glucose uptake. As with the ACN, oral administration of pure D3S5G dose-dependently decreased fasting blood glucose levels in obese C57BL/6J mice, and decreased glucose production in rat liver cells. D3S5G also increased glucose uptake in L6 myotubes and is at least partially responsible for ANC's anti-diabetic properties.

Idioma originalInglés
Páginas (desde-hasta)387-396
Número de páginas10
PublicaciónFood Chemistry
EstadoPublicada - 15 mar. 2012
Publicado de forma externa


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