Iodinated Polyesters with Enhanced X-ray Contrast Properties for Biomedical Imaging

Timothy R. Lex, Beau R. Brummel, Mohamed F. Attia, Lauren N. Giambalvo, Kinsey G. Lee, Brooke A. Van Horn, Daniel C. Whitehead, Frank Alexis

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

12 Citas (Scopus)

Resumen

Synthetic materials exhibiting contrast imaging properties have become vital to the field of biomedical imaging. However, polymeric biomaterials are lacking imaging contrast properties for deep tissue imaging. This report details the synthesis and characterization of a suite of aryl-iodo monomers, which were used to prepare iodinated polyesters using a pre-functionalization approach. Commercially available 4-iodo-phenylalanine or 4-iodobenzyl bromide served as the starting materials for the synthesis of three iodinated monomeric moieties (a modified lactide, morpholine-2,5-dione, and caprolactone), which under a tin-mediated ring-opening polymerization (ROP), generated their respective polyesters (PE) or poly(ester amides) (PEA). An increase in X-ray intensity of all synthesized iodine-containing polymers, in comparison to non-iodinated poly(lactic acid) (PLA), validated their functionality as radio-opaque materials. The iodinated-poly(lactic acid) (iPLA) material was visualized through varying thicknesses of chicken tissue, thus demonstrating its potenial as a radio-opaque biomaterial.

Idioma originalInglés
Número de artículo1508
PublicaciónScientific Reports
Volumen10
N.º1
DOI
EstadoPublicada - 1 dic. 2020
Publicado de forma externa

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