IS26 drives the dissemination of blaCTX-M genes in an Ecuadorian community

Liseth Salinas, Paúl Cárdenas, Jay P. Graham, Gabriel Trueba

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

IMPORTANCE: The horizontal gene transfer events are the major contributors to the current spread of CTX-M-encoding genes, the most common extended-spectrum β-lactamase (ESBL), and many clinically crucial antimicrobial resistance (AMR) genes. This study presents evidence of the critical role of IS26 transposable element for the mobility of blaCTX-M gene among Escherichia coli isolates from children and domestic animals in the community. We suggest that the nucleotide sequences of IS26-blaCTX-M could be used to study blaCTX-M transmission between humans, domestic animals, and the environment, because understanding of the dissemination patterns of AMR genes is critical to implement effective measures to slow down the dissemination of these clinically important genes.

Idioma originalInglés
Páginas (desde-hasta)e0250423
PublicaciónMicrobiology spectrum
Volumen12
N.º1
DOI
EstadoPublicada - 11 ene. 2024

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