TY - JOUR
T1 - Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population
AU - Levine, Morgan E.
AU - Suarez, Jorge A.
AU - Brandhorst, Sebastian
AU - Balasubramanian, Priya
AU - Cheng, Chia Wei
AU - Madia, Federica
AU - Fontana, Luigi
AU - Mirisola, Mario G.
AU - Guevara-Aguirre, Jaime
AU - Wan, Junxiang
AU - Passarino, Giuseppe
AU - Kennedy, Brian K.
AU - Wei, Min
AU - Cohen, Pinchas
AU - Crimmins, Eileen M.
AU - Longo, Valter D.
N1 - Funding Information:
GHRKO (C57BL/6 background) mice were kindly provided by J.J. Kopchick (Ohio University). This work was funded by NIH/NIA grants (AG20642, AG025135, and AG034906) to V.D.L., NIH/NIA grants (P30AG017265 and T32AG0037) to E.M.C., and a USC Norris Cancer Center pilot grant to V.D.L. The funding sources had no involvement in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. V.D.L. has equity interest in L-Nutra, a company that develops medical food. The other authors declare that they have no conflicts of interest.
PY - 2014/3/4
Y1 - 2014/3/4
N2 - Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50-65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.
AB - Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50-65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.
UR - http://www.scopus.com/inward/record.url?scp=84895727751&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2014.02.006
DO - 10.1016/j.cmet.2014.02.006
M3 - Artículo
C2 - 24606898
AN - SCOPUS:84895727751
SN - 1550-4131
VL - 19
SP - 407
EP - 417
JO - Cell Metabolism
JF - Cell Metabolism
IS - 3
ER -
