This work applies green engineering, zero-waste, bioeconomy, biorefining and circular economy concepts around mango fruit waste. Fruit and vegetable industrialization by-products contain valuable chemical compounds called secondary metabolites and structural biopolymers, considered renewable raw materials with significant properties and characteristics that can be recovered and converted in high value-added compounds. These can be incorporated in new applications in pharmaceutical, food, nutraceuticals, cosmetics, textiles, pulp and paper, among other industries. Mango residual biomass was submitted to pigments and oil extraction. Besides using classic solvents for the extraction of bioactive chemicals, the novel aspect of this project is to use deep eutectic solvents (DES) for oil/butter extraction from the mango kernel. Moreover, mango peel flour and mango-derived biofilters (endocarp) have been used for the removal of carbamazepine, ibuprofen and acesulfame from artificial water.