Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis

Danila Cianciosi; Tamara Y. Forbes-Hernández; Lucia Regolo; José M. Alvarez-Suarez; Denise Quinzi; Azzurra Sargenti; Weibin Bai; Lingmin Tian; Francesca Giampieri; Maurizio Battino

doi:10.1016/j.foodchem.2021.131753

Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis

Danila Cianciosi, Tamara Y. Forbes-Hernández, Lucia Regolo, José M. Alvarez-Suarez, Denise Quinzi, Azzurra Sargenti, Weibin Bai, Lingmin Tian, Francesca Giampieri, Maurizio Battino

Ingeniería en Alimentos

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Resumen

The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.

Idioma original	Inglés
Número de artículo	131753
Publicación	Food Chemistry
Volumen	374
DOI	https://doi.org/10.1016/j.foodchem.2021.131753
Estado	Publicada - 16 abr. 2022

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Cianciosi, D., Forbes-Hernández, T. Y., Regolo, L., Alvarez-Suarez, J. M., Quinzi, D., Sargenti, A., Bai, W., Tian, L., Giampieri, F., & Battino, M. (2022). Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis. Food Chemistry, 374, Artículo 131753. https://doi.org/10.1016/j.foodchem.2021.131753

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title = "Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis",

abstract = "The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.",

keywords = "Apoptosis, Cancer, Chemosensibility, Honey, Spheroids, Stemness",

author = "Danila Cianciosi and Forbes-Hern{\'a}ndez, {Tamara Y.} and Lucia Regolo and Alvarez-Suarez, {Jos{\'e} M.} and Denise Quinzi and Azzurra Sargenti and Weibin Bai and Lingmin Tian and Francesca Giampieri and Maurizio Battino",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = apr,

day = "16",

doi = "10.1016/j.foodchem.2021.131753",

language = "Ingl{\'e}s",

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Cianciosi, D, Forbes-Hernández, TY, Regolo, L, Alvarez-Suarez, JM, Quinzi, D, Sargenti, A, Bai, W, Tian, L, Giampieri, F & Battino, M 2022, 'Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis', Food Chemistry, vol. 374, 131753. https://doi.org/10.1016/j.foodchem.2021.131753

Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis. / Cianciosi, Danila; Forbes-Hernández, Tamara Y.; Regolo, Lucia et al.
En: Food Chemistry, Vol. 374, 131753, 16.04.2022.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis

AU - Cianciosi, Danila

AU - Forbes-Hernández, Tamara Y.

AU - Regolo, Lucia

AU - Alvarez-Suarez, José M.

AU - Quinzi, Denise

AU - Sargenti, Azzurra

AU - Bai, Weibin

AU - Tian, Lingmin

AU - Giampieri, Francesca

AU - Battino, Maurizio

PY - 2022/4/16

Y1 - 2022/4/16

N2 - The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.

AB - The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.

KW - Apoptosis

KW - Cancer

KW - Chemosensibility

KW - Honey

KW - Spheroids

KW - Stemness

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U2 - 10.1016/j.foodchem.2021.131753

DO - 10.1016/j.foodchem.2021.131753

M3 - Artículo

C2 - 34883427

AN - SCOPUS:85120850493

SN - 0308-8146

VL - 374

JO - Food Chemistry

JF - Food Chemistry

M1 - 131753

ER -

Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis

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