Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis

Danila Cianciosi, Tamara Y. Forbes-Hernández, Lucia Regolo, José M. Alvarez-Suarez, Denise Quinzi, Azzurra Sargenti, Weibin Bai, Lingmin Tian, Francesca Giampieri, Maurizio Battino

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9 Citas (Scopus)

Resumen

The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.

Idioma originalInglés
Número de artículo131753
PublicaciónFood Chemistry
Volumen374
DOI
EstadoPublicada - 16 abr. 2022

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