TY - JOUR
T1 - Many neglected tropical diseases may have originated in the Paleolithic or before
T2 - New insights from genetics
AU - Trueba, Gabriel
AU - Dunthorn, Micah
N1 - Funding Information:
We would like to thank the support of Universidad San Francisco de Quito to GT, and the Alexander von Humboldt Foundation to MD. Thanks also goes to Ricardo Vásquez for the figure and Felix Lankester for his valuable input.
PY - 2012/3
Y1 - 2012/3
N2 - The standard view of modern human infectious diseases is that many of them arose during the Neolithic when animals were first domesticated, or afterwards. Here we review recent genetic and molecular clock estimates that point to a much older Paleolithic origin (2.5 million years ago to 10,000 years ago) of some of these diseases. During part of this ancient period our early human ancestors were still isolated in Africa. We also discuss the need for investigations of the origin of these diseases in African primates and other animals that have been the original source of many neglected tropical diseases.
AB - The standard view of modern human infectious diseases is that many of them arose during the Neolithic when animals were first domesticated, or afterwards. Here we review recent genetic and molecular clock estimates that point to a much older Paleolithic origin (2.5 million years ago to 10,000 years ago) of some of these diseases. During part of this ancient period our early human ancestors were still isolated in Africa. We also discuss the need for investigations of the origin of these diseases in African primates and other animals that have been the original source of many neglected tropical diseases.
UR - http://www.scopus.com/inward/record.url?scp=84859206090&partnerID=8YFLogxK
U2 - 10.1371/journal.pntd.0001393
DO - 10.1371/journal.pntd.0001393
M3 - Artículo de revisión
C2 - 22479653
AN - SCOPUS:84859206090
SN - 1935-2727
VL - 6
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
IS - 3
M1 - e1393
ER -
