Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Thomas L. Moore; Stuart W. Grimes; Robert L. Lewis; Frank Alexis

doi:10.1021/mp400448w

Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Thomas L. Moore, Stuart W. Grimes, Robert L. Lewis, Frank Alexis

Clemson University College of Engineering, Computing and Applied Sciences

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

37 Citas (Scopus)

Resumen

Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

Idioma original	Inglés
Páginas (desde-hasta)	276-282
Número de páginas	7
Publicación	Molecular Pharmaceutics
Volumen	11
N.º	1
DOI	https://doi.org/10.1021/mp400448w
Estado	Publicada - 6 ene. 2014
Publicado de forma externa	Sí

Acceder al documento

10.1021/mp400448w

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{85be7f97a61d4d1ca6204b91c28e0e12,

title = "Multilayered polymer-coated carbon nanotubes to deliver dasatinib",

abstract = "Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.",

keywords = "carbon nanotube, encapsulation, multilayered polymer coatings, synthesis",

author = "Moore, {Thomas L.} and Grimes, {Stuart W.} and Lewis, {Robert L.} and Frank Alexis",

year = "2014",

month = jan,

day = "6",

doi = "10.1021/mp400448w",

language = "Ingl{\'e}s",

volume = "11",

pages = "276--282",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

number = "1",

}

TY - JOUR

T1 - Multilayered polymer-coated carbon nanotubes to deliver dasatinib

AU - Moore, Thomas L.

AU - Grimes, Stuart W.

AU - Lewis, Robert L.

AU - Alexis, Frank

PY - 2014/1/6

Y1 - 2014/1/6

N2 - Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

AB - Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

KW - carbon nanotube

KW - encapsulation

KW - multilayered polymer coatings

KW - synthesis

UR - http://www.scopus.com/inward/record.url?scp=84891753122&partnerID=8YFLogxK

U2 - 10.1021/mp400448w

DO - 10.1021/mp400448w

M3 - Artículo

C2 - 24294824

AN - SCOPUS:84891753122

SN - 1543-8384

VL - 11

SP - 276

EP - 282

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

IS - 1

ER -

Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Resumen

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto