Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Thomas L. Moore, Stuart W. Grimes, Robert L. Lewis, Frank Alexis

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

33 Citas (Scopus)

Resumen

Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

Idioma originalInglés
Páginas (desde-hasta)276-282
Número de páginas7
PublicaciónMolecular Pharmaceutics
Volumen11
N.º1
DOI
EstadoPublicada - 6 ene. 2014
Publicado de forma externa

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