Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Thomas L. Moore; Stuart W. Grimes; Robert L. Lewis; Frank Alexis

doi:10.1021/mp400448w

Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Thomas L. Moore
, Stuart W. Grimes
, Robert L. Lewis
, Frank Alexis^*

^*Autor correspondiente de este trabajo

Clemson University College of Engineering, Computing and Applied Sciences

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

39 Citas (Scopus)

Resumen

Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

Idioma original	Inglés
Páginas (desde-hasta)	276-282
Número de páginas	7
Publicación	Molecular Pharmaceutics
Volumen	11
N.º	1
DOI	https://doi.org/10.1021/mp400448w
Estado	Publicada - 6 ene 2014
Publicado de forma externa	Sí

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abstract = "Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.",

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author = "Moore, \{Thomas L.\} and Grimes, \{Stuart W.\} and Lewis, \{Robert L.\} and Frank Alexis",

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doi = "10.1021/mp400448w",

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AU - Moore, Thomas L.

AU - Grimes, Stuart W.

AU - Lewis, Robert L.

AU - Alexis, Frank

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AB - Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

KW - carbon nanotube

KW - encapsulation

KW - multilayered polymer coatings

KW - synthesis

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Multilayered polymer-coated carbon nanotubes to deliver dasatinib

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