This paper presents a comparison of Isolated (Flyback) and non-Isolated (Buck) multiple input-single output (MISO) DC-DC converters. The analysis of DC-DC converters is based on pulsed voltage source cells (PVSC). The modeling of both converter types is detailed through their mathematical models and electrical simulations using Matlab/Simulink and PSIM. The comparison focuses on the sizing parameters, non-ideal output characteristics and efficiency. Results show that the output voltage of the MISO Buck converter exhibits a linear dependence on the duty cycles control signal and has slightly higher efficiency than the Flyback converter. To validate the operation of both converters, a scenario with two inputs (low-power hydroelectric and photovoltaic voltage sources) is considered. The modeling and control of both source systems are detailed and the MISO converter performance response is evaluated under sources changes and efficiency point of view.