Nanoparticles to Cross Biological Barriers

Thomas Moore; Elizabeth Graham; Brandon Mattix; Frank Alexis

doi:10.1201/b12303-8

Nanoparticles to Cross Biological Barriers

Thomas Moore
, Elizabeth Graham
, Brandon Mattix
, Frank Alexis

Clemson University College of Engineering, Computing and Applied Sciences

Producción científica: Capítulo del libro/informe/acta de congreso › Capítulo › revisión exhaustiva

7 Citas (Scopus)

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KEY TERMS: Drug delivery, pulmonary delivery, oral delivery, nasal delivery, transdermal delivery, circulation time, biodistribution, excretion, blood-brain barrier Polymeric nanoparticle delivery systems have the potential to signicantly impact the treatment of cancer. Nanoparticle drug delivery systems offer the ability to design a delivery vehicle that maximizes the therapeutic index of a drug encapsulated into nanoparticles (NPs), target it to cancerous tissue, and release it in a controlled manner for optimal dosing. This chapter describes the barriers associated with various delivery routes, specically tissue, cellular, and molecular. Nanoparticle delivery approaches across tissue barriers CONTENTS Abstract …………………………………………………………………………………………………….85 Introduction ……………………………………………………………………………………………..86 Clinical Impact of NPDDS……………………………………………………………………….. 87 Crossing Epithelial Barriers ………………………………………………………………………88.

Idioma original	Inglés
Título de la publicación alojada	Biomaterials Science
Subtítulo de la publicación alojada	An Integrated Clinical and Engineering Approach
Editorial	CRC Press
Páginas	85-122
Número de páginas	38
ISBN (versión digital)	9781439804056
ISBN (versión impresa)	9780367381257
DOI	https://doi.org/10.1201/b12303-8
Estado	Publicada - 1 ene. 2012
Publicado de forma externa	Sí

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abstract = "KEY TERMS: Drug delivery, pulmonary delivery, oral delivery, nasal delivery, transdermal delivery, circulation time, biodistribution, excretion, blood-brain barrier Polymeric nanoparticle delivery systems have the potential to signicantly impact the treatment of cancer. Nanoparticle drug delivery systems offer the ability to design a delivery vehicle that maximizes the therapeutic index of a drug encapsulated into nanoparticles (NPs), target it to cancerous tissue, and release it in a controlled manner for optimal dosing. This chapter describes the barriers associated with various delivery routes, specically tissue, cellular, and molecular. Nanoparticle delivery approaches across tissue barriers CONTENTS Abstract …………………………………………………………………………………………………….85 Introduction ……………………………………………………………………………………………..86 Clinical Impact of NPDDS……………………………………………………………………….. 87 Crossing Epithelial Barriers ………………………………………………………………………88.",

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Nanoparticles to Cross Biological Barriers

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