New light on phosphate transfer from triesters

Anthony J. Kirby, José R. Mora, Faruk Nome

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

36 Citas (Scopus)


The reactivity of triesters is discussed in the general context of phosphate transfer, as usually studied for the reactions of mono- and diesters. Systematic work has typically concentrated on the Linear Free Energy Relationships measuring the dependence of reactivity on the nucleophile and the leaving group, but new results indicate that it can depend equally strongly on the two non-leaving (sometimes known as spectator) groups. This conclusion is supported by first results from theoretical calculations: which also predict that a two-step mechanism can be favored over a concerted SN2(P) mechanism even for reactions involving leaving groups as good as p-nitrophenolate. This article is part of a Special Issue entitled: Chemistry and mechanism of phosphatases, diesterases and triesterases.

Idioma originalInglés
Páginas (desde-hasta)454-463
Número de páginas10
PublicaciónBiochimica et Biophysica Acta - Proteins and Proteomics
EstadoPublicada - ene. 2013
Publicado de forma externa


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