Nutrition and rheumatoid arthritis in the ‘omics’ era

Manuela Cassotta, Tamara Y. Forbes-Hernandez, Danila Cianciosi, Maria Elexpuru Zabaleta, Sandra Sumalla Cano, Irma Dominguez, Beatriz Bullon, Lucia Regolo, Josè Miguel Alvarez-Suarez, Francesca Giampieri, Maurizio Battino

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16 Citas (Scopus)

Resumen

Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed.

Idioma originalInglés
Número de artículo763
Páginas (desde-hasta)1-25
Número de páginas25
PublicaciónNutrients
Volumen13
N.º3
DOI
EstadoPublicada - 1 mar. 2021
Publicado de forma externa

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