TY - JOUR
T1 - Nutritional value and preventive role of nigella sativa l. And its main component thymoquinone in cancer
T2 - An evidenced-based review of preclinical and clinical studies
AU - Ansary, Johura
AU - Giampieri, Francesca
AU - Forbes-Hernandez, Tamara Y.
AU - Regolo, Lucia
AU - Quinzi, Denise
AU - Villar, Santos Gracia
AU - Villena, Eduardo Garcia
AU - Pifarre, Kilian Tutusaus
AU - Alvarez-Suarez, José M.
AU - Battino, Maurizio
AU - Cianciosi, Danila
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/4/2
Y1 - 2021/4/2
N2 - In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals.
AB - In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals.
KW - Anticancer properties
KW - Com-bined therapy
KW - Molecular pathways
KW - Nigella sativa
KW - Nutritional composition
UR - http://www.scopus.com/inward/record.url?scp=85105185120&partnerID=8YFLogxK
U2 - 10.3390/molecules26082108
DO - 10.3390/molecules26082108
M3 - Artículo de revisión
C2 - 33916916
AN - SCOPUS:85105185120
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 8
M1 - 2108
ER -
