OXA-48 carbapenemase in Klebsiella pneumoniae sequence type 307 in Ecuador

José E. Villacís, Jorge A. Reyes, Hugo G. Castelán-Sánchez, Sonia Dávila-Ramos, Miguel Angel Lazo, Ahmad Wali, Luis A. Bodero, Yadira Toapanta, Cristina Naranjo, Lorena Montero, Josefina Campos, Marcelo G. Galas, Mónica C. Gestal

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6 Citas (Scopus)


Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. Klebsiella pneumoniae is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. K. pneumoniae sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of Klebsiella pneumoniae (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases.

Idioma originalInglés
Número de artículo435
EstadoPublicada - mar. 2020


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