Photoprotective potential of strawberry (Fragaria × ananassa) extract against UV-A irradiation damage on human fibroblasts

Francesca Giampieri, Josè M. Alvarez-Suarez, Sara Tulipani, Ana M. Gonzàles-Paramàs, Celestino Santos-Buelga, Stefano Bompadre, José L. Quiles, Bruno Mezzetti, Maurizio Battino

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

88 Citas (Scopus)

Resumen

Exposure to UV-A radiation is known to induce discrete lesions in DNA and the generation of free radicals that lead to a wide array of skin diseases. Strawberry (Fragaria × ananassa) contains several polyphenols with strong antioxidant and anti-inflammatory activities. Because the major representative components of strawberry are anthocyanins, these may significantly contribute to its properties. To test this hypothesis, methanolic extracts from the Sveva cultivar were analyzed for anthocyanin content and for their ability to protect human dermal fibroblasts against UV-A radiation, as assayed using 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenytetrazolium bromide and Comet assays. Five anthocyanin pigments were identified using high-performance liquid chromatography-diode array detection-electrospray ionization/mass spectrometry. Moreover, the strawberry extract showed a photoprotective activity in fibroblasts exposed to UV-A radiation, increasing cellular viability, and diminishing DNA damage, as compared to control cells. Overall, our data show that strawberry contains compounds that confer photoprotective activity in human cell lines and may protect skin against the adverse effects of UV-A radiation.

Idioma originalInglés
Páginas (desde-hasta)2322-2327
Número de páginas6
PublicaciónJournal of Agricultural and Food Chemistry
Volumen60
N.º9
DOI
EstadoPublicada - 7 mar. 2012
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Photoprotective potential of strawberry (Fragaria × ananassa) extract against UV-A irradiation damage on human fibroblasts'. En conjunto forman una huella única.

Citar esto