Pregnancy-Associated Cerebral Venous Thrombosis Presenting in the First Trimester: A Case Report

Cerebral venous thrombosis in pregnancy in the first trimester is a very rare condition but should not be confused with the clinical presentation of other common conditions in pregnancy such as pre-eclampsia. Although it is rare and difficult to diagnose, it is potentially serious and can increase maternal mortality. Diagnosis by imaging tests such as MRI and early treatment with heparin reduces maternal and perinatal morbidity and mortality. We present the case of a 39-year-old pregnant woman at 8 weeks’ gestation who presented with early onset of severe headache and vomiting; MRI with angiography revealed a thrombosis in the right transverse venous sinus. Early treatment based on anticoagulation with heparin and maintenance with warfarin allowed a favorable response without neurological sequelae in the acute phase and at subsequent follow-up. The physiological state of hypercoagulability of pregnancy could increase the occurrence of pathologies such as cerebral venous thrombosis. We report this case as the only one published in the local literature.