Prevalence and serotype specificity of rotavirus antibodies in different age groups of ecuadorian infants

Harald Briissow, Josette Sidoti, Denis Barclay, Jan Sotek, Henri Dirren, Wilma B. Freire

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

20 Citas (Scopus)

Resumen

The age-specific prevalence of antibody to rotavirus was studied in 1404 Ecuadorian children enrolled in a national nutrition and health survey. ELISA and neutralizing antibody analysis showed evidence for primary rotavirus infection in 6– to 12–month-old children, who showed also a more-than-three fold increase in significant diarrheal episodes in comparison with infants >6 months old. At this age, 56% of the sera with neutralizing antibody were monospecific. With increasing age a gradual decrease in prevalence of monospecific sera, to 10% in 5–year-old children, was observed. Monospecific sera were directed in decreasing frequency against serotypes 4 (56%), 3 (20%), 2 (14%), and 1 (10%). Serotype 4–specific antibody was acquired at an earlier age than were antibodies to the other serotypes, and 91% of sera with dual specificity neutralized serotype 4, whereas only 2% of sera that neutralized three serotypes failed to neutralize serotype 4.

Idioma originalInglés
Páginas (desde-hasta)615-620
Número de páginas6
PublicaciónJournal of Infectious Diseases
Volumen162
N.º3
DOI
EstadoPublicada - sep. 1990
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Prevalence and serotype specificity of rotavirus antibodies in different age groups of ecuadorian infants'. En conjunto forman una huella única.

Citar esto