Prevalence of VP4 and VP7 genotypes of human rotavirus in Ecuadorian children with acute diarrhea

Alfredo Naranjo, Cecilia Cedeño, Enrique Teran, Alejandro Castello, Patricio Barzallo, Bayron Guillen, Bolivar Mora, Orlando Echeverria, Jaime López, Cecilia Estrella, Walter Caicedo, Enrique Boloña, Julio López Campos, Raquel Moran, Iván Verduga, Mauricio Cabascango, Piedad Moya, Syayna Pandzic, Abel Barroso, Ines FernandezBolivar Muñoz, Elina Yanez, Luis Narvaez, Rosana Rota, Laura Esteban, Patricio Romero

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

9 Citas (Scopus)

Resumen

The objective of the present study was to determine rotavirus etiology and prevalence of the different rotavirus serotypes in Ecuadorian children younger than 5 years of age with gastroenteritis. Children (729) less than 5 years of age with acute diarrhea from either public or private primary health care centers in 10 different provinces of Ecuador, between March 2006 and August 2006 were included in the study. Rotavirus infection was diagnosed using a commercial immunoenzymatic test. Rotavirus isolated from stool samples was genotyped. Rotavirus was detected in the feces of 269 of the 729 children (37%) with diarrhea. The most prevalent G genotypes were G9 (46.1%) and G2 (27.2%), while the predominant P genotypes were P[8] (57%) and P[4] (29.5%). Among the single infections, the predominant P/G combinations were: P[8]G9 (56.9%) and P[4]G2 (32.6%). The present countrywide survey is one of the major studies for one single season in Latin America and the first in its class in Ecuador. The value of expanding laboratory capability throughout Latin America in order to monitor rotavirus strains over time, with special attention directed at those strains obtained from children who experience vaccine failure, is critical. Only continuous monitoring of rotavirus disease burden and genotype surveillance will provide this information.

Idioma originalInglés
Páginas (desde-hasta)1106-1111
Número de páginas6
PublicaciónJournal of Medical Virology
Volumen80
N.º6
DOI
EstadoPublicada - jun. 2008
Publicado de forma externa

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