Radiopharmacokinetics of Graphene Quantum Dots Nanoparticles In vivo: Comparing the Pharmacokinetics Parameters in Long and Short Periods

Matheus Keuper Bastos, Martha Sahylí Ortega Pijeira, Juliana Helena de Souza Sobrinho, Ana Paula dos Santos Matos, Eduardo Ricci-Junior, Pierre Basilio de Almeida Fechine, Luciana Magalhães Rebelo Alencar, Sara Gemini-Piperni, Frank Alexis, Mohamed Fathy Attia, Ralph Santos-Oliveira

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)


Background: Nanoparticles (NPs) have gained great importance during the last decades for developing new therapeutics with improved outcomes for biomedical applications due to their nanoscale size, surface properties, loading capacity, controlled drug release, and distribution. Among the carbon-based nanomaterials, one of the most biocompatible forms of graphene is gra-phene quantum dots (GQDs). GQDs are obtained by converting 2D graphene into zero-dimensional graphene nanosheets. Moreover, very few reports in the literature reported the pharmacokinetic studies proving the safety and effectiveness of GQDs for in vivo applications. Objectives: This study evaluated the pharmacokinetics of GQDs radiolabeled with99mTc, adminis-tered intravenously, in rodents (Wistar rats) in two conditions: short and long periods, to compare and understand the biological behavior. Methods: The graphene quantum dots were produced and characterized by RX diffractometry, Ra-man spectroscopy, and atomic force microscopy. The pharmacokinetic analysis was performed following the radiopharmacokinetics concepts, using radiolabeled graphene quantum dots with techne-tium 99 metastable (99mTc). The radiolabeling process of the graphene quantum dots with 99mTc was performed by the direct via. Results: The results indicate that the pharmacokinetic analyses with GQDs over a longer period were more accurate. Following a bicompartmental model, the long-time analysis considers each pharmacokinetic phase of drugs into the body. Furthermore, the data demonstrated that short-time analysis could lead to distortions in pharmacokinetic parameters, leading to misinterpretations. Conclusion: The evaluation of the pharmacokinetics of GQDs over long periods is more meaning-ful than the evaluation over short periods.

Idioma originalInglés
Páginas (desde-hasta)2527-2533
Número de páginas7
PublicaciónCurrent Topics in Medicinal Chemistry
EstadoPublicada - nov. 2022


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