TY - JOUR
T1 - Report of optic disc edema in growth hormone insensitive patients after treatment with insulin-like growth factor-I
AU - Guevara-Aguirre, Jaime
AU - Maldonado, Ramiro
AU - Koller, Elizabeth A.
AU - Martinez, V.
AU - Vasconez, O.
AU - Malozowski, Saul N.
PY - 1997/11
Y1 - 1997/11
N2 - Intracranial hypertension with papilledema has recently been reported with growth hormone administration. We present the case of a 14 year old female with growth hormone insensitivity syndrome (GHIS), who developed optic disc edema (ODE) within 30 days of the initiation of therapy with recombinant IGF-I (insulin-like growth factor I) (120 μg/kg BID). Symptoms may be intermittent, and thereby unreliable indicators of ODE. At least 5/131 patients with GHIS who have received IGF-I have developed this condition. Because of the high risk for developing ODE in this patient population, serial funduscopic examination is warranted for children receiving IDF-I.
AB - Intracranial hypertension with papilledema has recently been reported with growth hormone administration. We present the case of a 14 year old female with growth hormone insensitivity syndrome (GHIS), who developed optic disc edema (ODE) within 30 days of the initiation of therapy with recombinant IGF-I (insulin-like growth factor I) (120 μg/kg BID). Symptoms may be intermittent, and thereby unreliable indicators of ODE. At least 5/131 patients with GHIS who have received IGF-I have developed this condition. Because of the high risk for developing ODE in this patient population, serial funduscopic examination is warranted for children receiving IDF-I.
UR - http://www.scopus.com/inward/record.url?scp=0031425649&partnerID=8YFLogxK
M3 - Artículo
AN - SCOPUS:0031425649
SN - 1079-4794
VL - 29
SP - 384
EP - 391
JO - Annals of Ophthalmology - Glaucoma
JF - Annals of Ophthalmology - Glaucoma
IS - 6
ER -