Reproducibility in patterns of IGF generation with special reference to idiopathic short stature

Karin A. Selva, Caroline K. Buckway, Gary Sexton, Katherine L. Pratt, Efi Tjoeng, Jaime Guevara-Aguirre, Ron G. Rosenfeld

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

45 Citas (Scopus)


Background/Aim: Insulin-like growth factor I (IGF-I) and insulin-lke growth factor binding protein 3 (IGFBP-3) generation tests are both sensitive and specific measures of growth hormone (GH) sensitivity. Recently, the question of reproducibility of IGF generation tests has been raised. We report our analysis of the correlation of low-and high-dose GH IGF-I and IGFBP-3 generation tests among patients with GH deficiency, GH insensitivity, and idiopathic short stature. Methods: A total of 198 subjects were randomized to either high- or low-dose GH for 7 days; the alternate dose was received after a 2-week washout period. Samples were collected at baseline and on days 5 and 8 of GH administration. Results: The serum concentrations of IGF-I and IGFBP-3 correlated significantly from one test to the other, regardless of the diagnosis. In normal subjects and patients with GH insensitivity and GH deficiency, the delta over baseline in IGF-I and IGFBP-3 in the low-dose test was highly predictive of the delta values in the high-dose test. The delta correlation was greatly diminished, however, in the patient population having idiopathic short stature. Conclusions: These observations support partial GH insensitivity effecting IGF-I generation specifically, as a possible etiology for idiopathic short stature, and thus such patients may warrant appropriate biochemical and/or molecular evaluation for partial GH insensitivity.

Idioma originalInglés
Páginas (desde-hasta)237-246
Número de páginas10
PublicaciónHormone Research
EstadoPublicada - 2003
Publicado de forma externa


Profundice en los temas de investigación de 'Reproducibility in patterns of IGF generation with special reference to idiopathic short stature'. En conjunto forman una huella única.

Citar esto