TY - JOUR
T1 - Responsiveness of continuous ratings of dyspnea during exercise in patients with COPD
AU - Mahler, Donald A.
AU - Fierro-Carrion, Gustavo
AU - Mejia-Alfaro, Roberto
AU - Ward, Joseph
AU - Baird, John C.
PY - 2005/4
Y1 - 2005/4
N2 - Purpose: To examine the responsiveness of a new computerized method for patients to provide continuous ratings of dyspnea during exercise in patients with chronic obstructive pulmonary disease (COPD). Methods: In this randomized, double-blind study the effects of an inhaled bronchodilator (BD), albuterol/ipratropium bromide solution, were compared with normal saline (NS) in 30 patients with COPD (age, 66 ± 9 yr; forced expiratory volume in 1 s, 48 ± 14% pred). At visit 1, patients were familiarized with the cycle ergometer and computer, monitor, and mouse system to provide continuous ratings of dyspnea during exercise. At subsequent visits 2-3 d apart, patients performed pulmonary function tests followed by incremental ramp (15 W·min -1) and, 1 h later, constant work (at 55% of maximal work capacity) exercise tests. Results: During incremental exercise the slopes of V̇O 2:dyspnea and V̇E:dyspnea regressions were significantly lower, and patients exercised longer (Δ = 0.4 min; P = 0.003) with BD therapy compared with NS. During constant work exercise there was a significant reduction in dyspnea at the same exercise duration (5.0 ± 2.8 vs 6.2 ± 2.8 units on the 0-10 category-ratio scale; P = 0.02) and patients exercised longer (Δ = 0.9 min; P = 0.04) with BD therapy. Changes in lung function at rest did not correlate significantly with changes in dyspnea ratings during exercise. Conclusions: Continuous ratings of dyspnea were responsive to inhaled bronchodilator therapy during both incremental and constant work exercise tests in patients with symptomatic COPD.
AB - Purpose: To examine the responsiveness of a new computerized method for patients to provide continuous ratings of dyspnea during exercise in patients with chronic obstructive pulmonary disease (COPD). Methods: In this randomized, double-blind study the effects of an inhaled bronchodilator (BD), albuterol/ipratropium bromide solution, were compared with normal saline (NS) in 30 patients with COPD (age, 66 ± 9 yr; forced expiratory volume in 1 s, 48 ± 14% pred). At visit 1, patients were familiarized with the cycle ergometer and computer, monitor, and mouse system to provide continuous ratings of dyspnea during exercise. At subsequent visits 2-3 d apart, patients performed pulmonary function tests followed by incremental ramp (15 W·min -1) and, 1 h later, constant work (at 55% of maximal work capacity) exercise tests. Results: During incremental exercise the slopes of V̇O 2:dyspnea and V̇E:dyspnea regressions were significantly lower, and patients exercised longer (Δ = 0.4 min; P = 0.003) with BD therapy compared with NS. During constant work exercise there was a significant reduction in dyspnea at the same exercise duration (5.0 ± 2.8 vs 6.2 ± 2.8 units on the 0-10 category-ratio scale; P = 0.02) and patients exercised longer (Δ = 0.9 min; P = 0.04) with BD therapy. Changes in lung function at rest did not correlate significantly with changes in dyspnea ratings during exercise. Conclusions: Continuous ratings of dyspnea were responsive to inhaled bronchodilator therapy during both incremental and constant work exercise tests in patients with symptomatic COPD.
KW - Bronchodilator therapy
KW - Cardiopulmonary exercise testing
KW - Measurement of breathlessness
KW - Obstructive airway disease
KW - Pulmonary function testing
UR - http://www.scopus.com/inward/record.url?scp=16444380940&partnerID=8YFLogxK
U2 - 10.1249/01.MSS.0000158188.90833.38
DO - 10.1249/01.MSS.0000158188.90833.38
M3 - Artículo
C2 - 15809548
AN - SCOPUS:16444380940
SN - 0195-9131
VL - 37
SP - 529
EP - 535
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
IS - 4
ER -