Responsiveness of continuous ratings of dyspnea during exercise in patients with COPD

Donald A. Mahler, Gustavo Fierro-Carrion, Roberto Mejia-Alfaro, Joseph Ward, John C. Baird

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

18 Citas (Scopus)

Resumen

Purpose: To examine the responsiveness of a new computerized method for patients to provide continuous ratings of dyspnea during exercise in patients with chronic obstructive pulmonary disease (COPD). Methods: In this randomized, double-blind study the effects of an inhaled bronchodilator (BD), albuterol/ipratropium bromide solution, were compared with normal saline (NS) in 30 patients with COPD (age, 66 ± 9 yr; forced expiratory volume in 1 s, 48 ± 14% pred). At visit 1, patients were familiarized with the cycle ergometer and computer, monitor, and mouse system to provide continuous ratings of dyspnea during exercise. At subsequent visits 2-3 d apart, patients performed pulmonary function tests followed by incremental ramp (15 W·min -1) and, 1 h later, constant work (at 55% of maximal work capacity) exercise tests. Results: During incremental exercise the slopes of V̇O 2:dyspnea and V̇E:dyspnea regressions were significantly lower, and patients exercised longer (Δ = 0.4 min; P = 0.003) with BD therapy compared with NS. During constant work exercise there was a significant reduction in dyspnea at the same exercise duration (5.0 ± 2.8 vs 6.2 ± 2.8 units on the 0-10 category-ratio scale; P = 0.02) and patients exercised longer (Δ = 0.9 min; P = 0.04) with BD therapy. Changes in lung function at rest did not correlate significantly with changes in dyspnea ratings during exercise. Conclusions: Continuous ratings of dyspnea were responsive to inhaled bronchodilator therapy during both incremental and constant work exercise tests in patients with symptomatic COPD.

Idioma originalInglés
Páginas (desde-hasta)529-535
Número de páginas7
PublicaciónMedicine and Science in Sports and Exercise
Volumen37
N.º4
DOI
EstadoPublicada - abr. 2005
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Responsiveness of continuous ratings of dyspnea during exercise in patients with COPD'. En conjunto forman una huella única.

Citar esto