This article proposes Amazonia as a site to think world politics. The Amazon is invisible in the study International Relations (IR), yet its experiences are deeply global. I present the international dynamics at play in Amazonia at different historical moments to posit that this periphery has contributed to forging the political-economy of what is refer to as the core. The Amazon’s absence from the study of IR speaks about the larger inequality in processes of knowledge production. Serious engagements with Amazonia are one way to invite a plurality of worlds in the production of theories, disrupting global divisions of labor in knowledge production ally.