Some insight into hydrolytic scission mechanisms in bioerodible polyesters

Frank Alexis, Subbu Venkatraman, Santosh Kumar Rath, Leong Huat Gan

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

50 Citas (Scopus)

Resumen

PLLA, PDLLA, and PLGA copolymers have been studied to understand the details of their degradation behavior. All polymers exhibited a homogeneous mode of degradation, with uniform rates of degradation throughout the film. Crystallinity inhibited water absorption and hence retarded degradation. The degradation rate was increased by the presence of glycolic acid units in the PLGA copolymer; this effect overwhelms any decrease in degradation rate because of increased crystallinity due to the additional GA units. This effect is demonstrated quantitatively in this study. In PLGA polymers, there is evidence of unusual recrystallization behavior as degradation proceeds, due mainly to the higher rate of hydrolytic scission of the gly colide linkage compared with the lactide, as verified quantitatively with the use of 1H NMR studies. Application of a Monte Carlo model to the degradation results, however, appears to show a random scission process. The details of the mechanistic study of different factors influencing the process of degradation, as reported here, may have important implications in terms of selecting the right material for specific biomedical applications.

Idioma originalInglés
Páginas (desde-hasta)3111-3117
Número de páginas7
PublicaciónJournal of Applied Polymer Science
Volumen102
N.º4
DOI
EstadoPublicada - 15 nov. 2006
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Some insight into hydrolytic scission mechanisms in bioerodible polyesters'. En conjunto forman una huella única.

Citar esto