TY - JOUR
T1 - Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress
AU - Giampieri, Francesca
AU - Alvarez-Suarez, Jose M.
AU - Gasparrini, Massimiliano
AU - Forbes-Hernandez, Tamara Y.
AU - Afrin, Sadia
AU - Bompadre, Stefano
AU - Rubini, Corrado
AU - Zizzi, Antonio
AU - Astolfi, Paola
AU - Santos-Buelga, Celestino
AU - González-Paramás, Ana M.
AU - Quiles, Josè L.
AU - Mezzetti, Bruno
AU - Battino, Maurizio
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive compounds. The aim of the present study was to evaluate the protective effects of strawberry consumption against oxidative stress induced by Dox in rats. Animals were fed with strawberry enriched diet (15% of the total calories) for two months and Dox (10 mg/kg; i.p.) was injected at the end of the experimental period. Strawberry consumption significantly inhibited ROS production and oxidative damage biomarkers accumulation in plasma and liver tissue and alleviated histopathological changes in rat livers treated with Dox. The reduction of antioxidant enzyme activities was significantly mitigated after strawberry consumption. In addition, strawberry enriched diet ameliorated liver mitochondrial antioxidant levels and functionality. In conclusion, strawberry intake protects against Dox-induced toxicity, at plasma, liver and mitochondrial levels thanks to its high contents of bioactive compounds.
AB - Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive compounds. The aim of the present study was to evaluate the protective effects of strawberry consumption against oxidative stress induced by Dox in rats. Animals were fed with strawberry enriched diet (15% of the total calories) for two months and Dox (10 mg/kg; i.p.) was injected at the end of the experimental period. Strawberry consumption significantly inhibited ROS production and oxidative damage biomarkers accumulation in plasma and liver tissue and alleviated histopathological changes in rat livers treated with Dox. The reduction of antioxidant enzyme activities was significantly mitigated after strawberry consumption. In addition, strawberry enriched diet ameliorated liver mitochondrial antioxidant levels and functionality. In conclusion, strawberry intake protects against Dox-induced toxicity, at plasma, liver and mitochondrial levels thanks to its high contents of bioactive compounds.
KW - Bioactive compounds
KW - Doxorubicin
KW - Mitochondrial functionality
KW - Oxidative stress
KW - Strawberry
UR - http://www.scopus.com/inward/record.url?scp=84973867089&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2016.06.003
DO - 10.1016/j.fct.2016.06.003
M3 - Artículo
C2 - 27286747
AN - SCOPUS:84973867089
SN - 0278-6915
VL - 94
SP - 128
EP - 137
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
ER -