Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade

Francesca Giampieri, Josè M. Alvarez-Suarez, Mario D. Cordero, Massimiliano Gasparrini, Tamara Y. Forbes-Hernandez, Sadia Afrin, Celestino Santos-Buelga, Ana M. González-Paramás, Paola Astolfi, Corrado Rubini, Antonio Zizzi, Sara Tulipani, Josè L. Quiles, Bruno Mezzetti, Maurizio Battino

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

95 Citas (Scopus)

Resumen

Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8 weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P < 0.05). Furthermore, a significant (P < 0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression.

Idioma originalInglés
Páginas (desde-hasta)464-471
Número de páginas8
PublicaciónFood Chemistry
Volumen234
DOI
EstadoPublicada - 1 nov. 2017
Publicado de forma externa

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