Study of the initial stages of drug release from a degradable matrix of poly(d,l-lactide-co-glycolide)

Alexis Frank, Santosh Kumar Rath, Freddy Boey, Subbu Venkatraman

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

37 Citas (Scopus)


The initial stages of the in vitro degradation of and the drug release from a matrix made of poly(d,l-lactide-co-glycolide) was carried out in a phosphate buffer saline (pH 7.0) medium. It has been observed that substantial matrix degradation occurs at the end of 2 weeks of immersion. The drug release using films of the polymer shows a tri-phasic pattern, unlike the bi-phasic patterns usually seen. Mechanisms are proposed for each phase of release, based on results from weight loss, amount of water absorption and scanning electron microscopy. The details of the structural changes and their effects on drug release may have implications for delivering potent drugs over a 2-week period.

Idioma originalInglés
Páginas (desde-hasta)813-821
Número de páginas9
EstadoPublicada - feb. 2004
Publicado de forma externa


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