Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang, Vaishali Bagalkot, Christophoros C. Vasilliou, Frank Gu, Frank Alexis, Liangfang Zhang, Mariam Shaikh, Kai Yuet, Michael J. Cima, Robert Langer, Philip W. Kantoff, Neil H. Bander, Sangyong Jon, Omid C. Farokhzad

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

272 Citas (Scopus)

Resumen

(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

Idioma originalInglés
Páginas (desde-hasta)1311-1315
Número de páginas5
PublicaciónChemMedChem
Volumen3
N.º9
DOI
EstadoPublicada - 15 sep. 2008
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy'. En conjunto forman una huella única.

Citar esto