Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang; Vaishali Bagalkot; Christophoros C. Vasilliou; Frank Gu; Frank Alexis; Liangfang Zhang; Mariam Shaikh; Kai Yuet; Michael J. Cima; Robert Langer; Philip W. Kantoff; Neil H. Bander; Sangyong Jon; Omid C. Farokhzad

doi:10.1002/cmdc.200800091

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang, Vaishali Bagalkot, Christophoros C. Vasilliou, Frank Gu, Frank Alexis, Liangfang Zhang, Mariam Shaikh, Kai Yuet, Michael J. Cima, Robert Langer, Philip W. Kantoff, Neil H. Bander, Sangyong Jon, Omid C. Farokhzad

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283 Citas (Scopus)

Resumen

(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

Idioma original	Inglés
Páginas (desde-hasta)	1311-1315
Número de páginas	5
Publicación	ChemMedChem
Volumen	3
N.º	9
DOI	https://doi.org/10.1002/cmdc.200800091
Estado	Publicada - 15 sep. 2008
Publicado de forma externa	Sí

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Wang, A. Z., Bagalkot, V., Vasilliou, C. C., Gu, F., Alexis, F., Zhang, L., Shaikh, M., Yuet, K., Cima, M. J., Langer, R., Kantoff, P. W., Bander, N. H., Jon, S., & Farokhzad, O. C. (2008). Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem, 3(9), 1311-1315. https://doi.org/10.1002/cmdc.200800091

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abstract = "(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.",

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AU - Wang, Andrew Z.

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AU - Vasilliou, Christophoros C.

AU - Gu, Frank

AU - Alexis, Frank

AU - Zhang, Liangfang

AU - Shaikh, Mariam

AU - Yuet, Kai

AU - Cima, Michael J.

AU - Langer, Robert

AU - Kantoff, Philip W.

AU - Bander, Neil H.

AU - Jon, Sangyong

AU - Farokhzad, Omid C.

PY - 2008/9/15

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AB - (Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

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KW - Nanoparticles

KW - Superparamagnetic

KW - TCL-SPION

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Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

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