Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang; Vaishali Bagalkot; Christophoros C. Vasilliou; Frank Gu; Frank Alexis; Liangfang Zhang; Mariam Shaikh; Kai Yuet; Michael J. Cima; Robert Langer; Philip W. Kantoff; Neil H. Bander; Sangyong Jon; Omid C. Farokhzad

doi:10.1002/cmdc.200800091

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang
, Vaishali Bagalkot
, Christophoros C. Vasilliou
, Frank Gu
, Frank Alexis
, Liangfang Zhang
, Mariam Shaikh
, Kai Yuet
, Michael J. Cima
, Robert Langer
, Philip W. Kantoff
, Neil H. Bander
, Sangyong Jon^*
, Omid C. Farokhzad

^*Autor correspondiente de este trabajo

Brigham and Women's Hospital
Massachusetts Institute of Technology
Gwangju Institute of Science and Technology
Massachusetts Institute of Technology
Harvard University
Cornell University

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

294 Citas (Scopus)

Resumen

(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

Idioma original	Inglés
Páginas (desde-hasta)	1311-1315
Número de páginas	5
Publicación	ChemMedChem
Volumen	3
N.º	9
DOI	https://doi.org/10.1002/cmdc.200800091
Estado	Publicada - 15 sep. 2008
Publicado de forma externa	Sí

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Wang, A. Z., Bagalkot, V., Vasilliou, C. C., Gu, F., Alexis, F., Zhang, L., Shaikh, M., Yuet, K., Cima, M. J., Langer, R., Kantoff, P. W., Bander, N. H., Jon, S., & Farokhzad, O. C. (2008). Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem, 3(9), 1311-1315. https://doi.org/10.1002/cmdc.200800091

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abstract = "(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.",

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author = "Wang, \{Andrew Z.\} and Vaishali Bagalkot and Vasilliou, \{Christophoros C.\} and Frank Gu and Frank Alexis and Liangfang Zhang and Mariam Shaikh and Kai Yuet and Cima, \{Michael J.\} and Robert Langer and Kantoff, \{Philip W.\} and Bander, \{Neil H.\} and Sangyong Jon and Farokhzad, \{Omid C.\}",

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day = "15",

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AU - Wang, Andrew Z.

AU - Bagalkot, Vaishali

AU - Vasilliou, Christophoros C.

AU - Gu, Frank

AU - Alexis, Frank

AU - Zhang, Liangfang

AU - Shaikh, Mariam

AU - Yuet, Kai

AU - Cima, Michael J.

AU - Langer, Robert

AU - Kantoff, Philip W.

AU - Bander, Neil H.

AU - Jon, Sangyong

AU - Farokhzad, Omid C.

PY - 2008/9/15

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N2 - (Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

AB - (Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

KW - Doxorubicin

KW - Nanoparticles

KW - Superparamagnetic

KW - TCL-SPION

UR - https://www.scopus.com/pages/publications/54849404705

U2 - 10.1002/cmdc.200800091

DO - 10.1002/cmdc.200800091

M3 - Artículo

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AN - SCOPUS:54849404705

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JO - ChemMedChem

JF - ChemMedChem

IS - 9

ER -

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

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