Synthesis and conjugation of a triiodohydroxylamine for the preparation of highly X-ray opaque poly(ε-caprolactone) materials

To address a need for highly X-ray opaque biodegradable materials, a series of poly(ε-caprolactone) derivatives were prepared using oxime post-polymerization modification to conjugate two different iodinated hydroxylamines. These materials were synthesized with up to 32 wt. % iodine content and demonstrated improved X-ray contrast relative to both the ketone precursors and previously reported monoiodinated materials.