TY - JOUR
T1 - The effects of bioactive compounds from plant foods on mitochondrial function
T2 - A focus on apoptotic mechanisms
AU - Forbes-Hernández, Tamara Y.
AU - Giampieri, Francesca
AU - Gasparrini, Massimiliano
AU - Mazzoni, Luca
AU - Quiles, José L.
AU - Alvarez-Suarez, José M.
AU - Battino, Maurizio
PY - 2014/6
Y1 - 2014/6
N2 - Mitochondria are essential organelles for cellular integrity and functionality maintenance and their imparement is implicated in the development of a wide range of diseases, including metabolic, cardiovascular, degenerative and hyperproliferative pathologies. The identification of different compounds able to interact with mitochondria for therapeutic purposes is currently becoming of primary importance. Indeed, it is well known that foods, particularly those of vegetable origin, present several constituents with beneficial effects on health. This review summarizes and updates the most recent findings concerning the mechanisms through which different dietary compounds from plant foods affect mitochondria functionality in healthy and pathological in vitro and in vivo models, paying particular attention to the pathways involved in mitochondrial biogenesis and apoptosis.
AB - Mitochondria are essential organelles for cellular integrity and functionality maintenance and their imparement is implicated in the development of a wide range of diseases, including metabolic, cardiovascular, degenerative and hyperproliferative pathologies. The identification of different compounds able to interact with mitochondria for therapeutic purposes is currently becoming of primary importance. Indeed, it is well known that foods, particularly those of vegetable origin, present several constituents with beneficial effects on health. This review summarizes and updates the most recent findings concerning the mechanisms through which different dietary compounds from plant foods affect mitochondria functionality in healthy and pathological in vitro and in vivo models, paying particular attention to the pathways involved in mitochondrial biogenesis and apoptosis.
KW - Apoptosis
KW - Dietary bioactive compounds
KW - Mitocondrial functionality
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84898921407&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2014.03.017
DO - 10.1016/j.fct.2014.03.017
M3 - Artículo de revisión
C2 - 24680691
AN - SCOPUS:84898921407
SN - 0278-6915
VL - 68
SP - 154
EP - 182
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
ER -