The IFITM protein family in adaptive immunity

Diana C. Yánez, Susan Ross, Tessa Crompton

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

73 Citas (Scopus)


Interferon-inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification (IFITM1–IFITM3), osteoblast function and bone mineralization (IFITM5) and immune functions (IFITM1–3, IFITM6). IFITM1–3 are expressed by T cells and recent experiments have shown that the IFITM proteins are directly involved in adaptive immunity and that they regulate CD4+ T helper cell differentiation in a T-cell-intrinsic manner. Here we review the role of the IFITM proteins in T-cell differentiation and function.

Idioma originalInglés
Páginas (desde-hasta)365-372
Número de páginas8
EstadoPublicada - 1 abr. 2020


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