The role of H-bonding in the structure of the 4-piperidinecarboxylic acid monohydrate

Asiloé J. Mora, Gerzon Delgado, Belkis M. Ramírez, Luis Rincón, Rafael Almeida, Javier Cuervo, Alí Bahsas

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

20 Citas (Scopus)

Resumen

In this work we have investigated the hydrogen bond scheme of 4-piperidinecarboxylic (isonipecotic) acid by means of X-ray diffraction, NMR spectroscopy and semi-empirical calculations. The 4-piperidinecarboxylic acid displays a three-dimensional assembly of hydrogen bonds. Hence, infinite chains of amino acid molecules linked by amino-carboxylate intermolecular hydrogen bonds run parallel to the b and c axes; additionally, chains of amino acid molecules intercalated with water molecules held together by water-carboxylate hydrogen bonds run parallel to the a axis. The theoretical calculations show large cooperative effects for the first of the amino acid chains mentioned above, which is manifested as shortening on the amino-carboxylate hydrogen bond distances and decreasing of the hydrogen bond enthalpies per monomer of the hydrogen bonded clusters, with increment of monomers in the chain.

Idioma originalInglés
Páginas (desde-hasta)201-208
Número de páginas8
PublicaciónJournal of Molecular Structure
Volumen615
N.º1-3
DOI
EstadoPublicada - 26 sep. 2002
Publicado de forma externa

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