TY - JOUR
T1 - Tissue-specific disruption of the growth hormone receptor (GHR) in mice
T2 - An update
AU - Duran-Ortiz, Silvana
AU - Noboa, Vanessa
AU - Kopchick, John J.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/4
Y1 - 2020/4
N2 - The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.
AB - The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.
KW - Adipose tissue
KW - Bone
KW - Brain
KW - Growth hormone receptor
KW - Heart
KW - IGF-I
KW - Intestine
KW - Liver
KW - Macrophages
KW - Tissue-specific
UR - http://www.scopus.com/inward/record.url?scp=85077396376&partnerID=8YFLogxK
U2 - 10.1016/j.ghir.2019.12.004
DO - 10.1016/j.ghir.2019.12.004
M3 - Artículo
C2 - 31923746
AN - SCOPUS:85077396376
SN - 1096-6374
VL - 51
SP - 1
EP - 5
JO - Growth Hormone and IGF Research
JF - Growth Hormone and IGF Research
ER -
