Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

Silvana Duran-Ortiz; Vanessa Noboa; John J. Kopchick

doi:10.1016/j.ghir.2019.12.004

Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

Silvana Duran-Ortiz
, Vanessa Noboa
, John J. Kopchick^*

^*Autor correspondiente de este trabajo

Medicina

Ohio University
Molecular and Cellular Biology Program
Ohio University

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

8 Citas (Scopus)

Resumen

The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.

Idioma original	Inglés
Páginas (desde-hasta)	1-5
Número de páginas	5
Publicación	Growth Hormone and IGF Research
Volumen	51
DOI	https://doi.org/10.1016/j.ghir.2019.12.004
Estado	Publicada - abr. 2020

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title = "Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update",

abstract = "The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.",

keywords = "Adipose tissue, Bone, Brain, Growth hormone receptor, Heart, IGF-I, Intestine, Liver, Macrophages, Tissue-specific",

author = "Silvana Duran-Ortiz and Vanessa Noboa and Kopchick, \{John J.\}",

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T2 - An update

AU - Duran-Ortiz, Silvana

AU - Noboa, Vanessa

AU - Kopchick, John J.

PY - 2020/4

Y1 - 2020/4

N2 - The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.

AB - The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.

KW - Adipose tissue

KW - Bone

KW - Brain

KW - Growth hormone receptor

KW - Heart

KW - IGF-I

KW - Intestine

KW - Liver

KW - Macrophages

KW - Tissue-specific

UR - https://www.scopus.com/pages/publications/85077396376

U2 - 10.1016/j.ghir.2019.12.004

DO - 10.1016/j.ghir.2019.12.004

M3 - Artículo

C2 - 31923746

AN - SCOPUS:85077396376

SN - 1096-6374

VL - 51

SP - 1

EP - 5

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

ER -

Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

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