Ultrasonido doppler transcraneal en la prevención del accidente vascular encefálico en niños con drepanocitosis

Andrea Menéndez Veitía, Alberto Arencibia Núñez, Marilyn Chaviano de León, Eva Svarch, Claudio Scherle Matamoros, Alejandro González Otero, Sergio Machín García, Jesús Serrano Mirabal, Adys I. Gutiérrez Díaz, Tamara Delgado Vargas, Francisco Valdés Cabrera

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Introduction: neurological complications and their sequelae are known almost since the first description of sickle cell disease, most commonly in sickle cell anemia. They vary with age, can be acute or chronic and produce high morbidity and mortality. Aims: to determine the frequency of children with AD who have alterations in cerebral blood flow velocity, relate these changes to clinical events and laboratory data and assess the evolution over time of patients with abnormalities and their association with the use of hydroxyurea. Methods: a prospective analytical study involving 50 patients with sickle cell disease, aged 5 to 18, was performed in at the Institute of Hematology and Immunology where they are assisted. Alterations in cerebral blood flow (CBF) and the association with other clinical and hematological elements were determined. Results: the arteries that showed larger speed were right middle cerebral artery (121.6 cm/s) and left (115 cm/s). Patients with impaired CBF velocity in transcranial Doppler ultrasound were 11 (22%) with speeds greater higher than 170 cm/s, 6 patients (12%) with a flow between 170-199 cm/s, and five (10%) greater higher than 200 cm/s. There was an inverse correlation between Cbf velocity with age and hemoglobin levels and directly with the platelet count. The cerebrovascular accident, blood transfusions and hospitalizations were the most frequent clinical events in patients with abnormal transcranial doppler ultrasound. FSC velocities were significantly decreased (31 cm /s; p = 0,034) in patients receiving treatment with hydroxyurea. Conclusions: Patients with alterations in the transcranial Doppler ultrasound must be included in a program for primary prevention of cerebrovascular accident.

Título traducido de la contribuciónTranscranial doppler ultrasound in the prevention of cerebrovascular accident in children with sickle cell disease
Idioma originalEspañol
Páginas (desde-hasta)405-416
Número de páginas12
PublicaciónRevista Cubana de Hematologia, Inmunologia y Hemoterapia
Volumen31
N.º4
EstadoPublicada - oct. 2015
Publicado de forma externa

Palabras clave

  • Cerebrovascular accident prevention
  • Sickle cell disease
  • Transcranial doppler ultrasound

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